Sonja Haupt

Sonja Haupt, Postdoc

Contact details

Phone: 0131-650-8622

Location: Office 1.08, Ashworth Laboratories

Research interests

I joined Rose’s Lab in November 2015 and I am currently working on targeting intracellular signalling molecules in human T cells as a viable strategy to improve adoptive T cell therapy. I am using CRISPR/Cas9 manipulation to delete expression of PTPN22 in primary human T cells to test whether that improves their anti-tumour effector function.

Main laboratory techniques

CRISPR/Cas9
Flow cytometry
In vitro culture
Transfection
Transduction
Molecular biology techniques

Additional activities

Since February 2017

Committee member of Edinburgh Cancer Immunology

Since November 2016

Immunology 3 Tutorials (Providing tutorial for group of 8-12 students)

Publications

Haupt S, Söntgerath VS, Leipe J, Schulze-Koops H, Skapenko A. Methylation of an intragenic alternative promoter regulates transcription of GARP. Biochim Biophys Acta. 2016 Feb;1859(2):223-34.

Zhou Q*, Haupt S*, Kreuzer JT, Hammitzsch A, Proft F, Neumann C, Leipe J, Witt M, Schulze-Koops H, Skapenko A. Decreased expression of miR-146a and miR-155 contributes to an abnormal Treg phenotype in patients with rheumatoid arthritis. Ann Rheum Dis. 2015 Jun;74(6):1265-74. (*Shared first author)

Zhou Q, Haupt S, Prots I, Thümmler K, Kremmer E, Lipsky PE, Schulze-Koops H, Skapenko A. miR-142-3p is involved in CD25+ CD4 T cell proliferation by targeting the expression of glycoprotein A repetitions predominant. J Immunol. 2013 Jun 15;190(12):6579-88.

Haupt S, Tisdale M, Vincendeau M, Clements MA, Gauthier DT, Lance R, Semmes OJ, Turqueti-Neves A, Noessner E, Leib-Mösch C, Greenwood AD. Human endogenous retrovirus transcription profiles of the kidney and kidney-derived cell lines. J Gen Virol. 2011 Oct;92(Pt 10):2356-66.

Scherb J, Kreissl J, Haupt S, Schieberle P. Quantitation of S-methylmethionine in raw vegetables and green malt by a stable isotope dilution assay using LC-MS/MS: comparison with dimethyl sulfide formation after heat treatment. J Agric Food Chem. 2009 Oct 14;57(19):9091-6.

Short biography

Since 11/2015

Postdoc on adoptive T cell therapy

Institute of Immunology and Infection Research, University of Edinburgh

Research group of Prof. Dr. Rose Zamoyska

05/2010 – 08/2015

PhD on regulatory T cell function in rheumatoid arthritis

Division of Rheumatology and Clinical Immunology, LMU Munich

Research group of Dr. Alla Skapenko

10/2007 – 08/2009

MSc in Biochemistry at TU Munich

10/2004 – 08/2007

BSc in Biology at University of Münster