Johanna Knipper, Postdoc
- Email: firstname.lastname@example.org
- Phone: 0131-650-8685
- Location: Office 1.01, Ashworth Laboratories
Since I joined Rose’s Lab in September 2016 my main research focus is the role PTPN22 plays in T cell activation its implication for the onset of autoimmunity. The loss of PTPN22 in T cells leads to an expansion of the memory/effector T cell population. However PTPN22 deficiency does not induce pathology or any signs of autoimmune diseases in mice in steady state. Similarly, a substantial proportion of humans carrying a mutation in PTPN22 never develop autoimmunity although they are predisposed. I’m trying to understand by which mechanism the expanded memory/effector T cell population is kept in check and under which circumstances this balance is challenged.
My undergraduate studies in biology were very broad, ranging from plant genetics over microbiology to zoology. I became mostly fascinated by the complex regulation of immune response and it was clear for me to pursue immunology. During my PhD in Sabine Eming’s Lab at the University of Cologne I investigated the role the innate immune response plays in tissue repair and regeneration after injury. I identified macrophage activated by type 2 immune signals as critical for efficient skin repair. Moving to Edinburgh for my first Postdoc in Matt Taylor’s lab I started working on the functional and phenotypical changes of effector T helper cells in chronic helminth infections, using Microarray and RNAseq analysis to investigate T cell plasticity.
In my career, I have worked with many different models and on different cells types to find answers to the same fundamental questions: What makes a successful immune response, what permits persistent and chronic inflammation and what maintains immunological tolerance.
- Secretary of the Edinburgh Immunology Group, a regional Group of the British Society for Immunology. We invite international and national scientist to speak about their immunology-related reserach at our seminar series and conferences in Edinburgh. For more info please visit: https://www.immunology.org/about-us/our-people/regional-and-affinity-gro...
- Founding Member of the Postdoc Committee at the School of Biological Sciences at the Univerity of Edinburgh (since 2018)
- Reviewer for the Journal of Wound Repair and Regeneration and MDPI Journals (since 2015)
- Supervisor Student Projects (since 2015)
- Tutor for Immunology 3, providing tutorials for a group of 8-12 students (since 2014)
Knipper JA, Ding X, Eming SA. Diabetes Impedes the Epigenetic Switch of Macrophages into Repair Mode. Immunity. 2019 Aug 20;51(2):199-201. doi: 10.1016/j.immuni.2019.07.009.
Zaiss DM, Minutti CM, Knipper JA. Immune- and non-immune-mediated roles of regulatory T-cells during wound healing. Immunology. 2019 Jul;157(3):190-197. doi: 10.1111/imm.13057. Epub 2019 Apr 9. Review.
Campbell SM, Knipper JA, Ruckerl D, Finlay CM, Logan N, Minutti CM, Mack M, Jenkins SJ, Taylor MD, Allen JE. Myeloid cell recruitment versus local proliferation differentiates susceptibility from resistance to filarial infection. Elife. 2018 Jan 4;7. pii: e30947. doi: 10.7554/eLife.30947.
Minutti CM, Jackson-Jones LH, García-Fojeda B, Knipper JA, Sutherland TE, Logan N, Rinqvist E, Guillamat-Prats R, Ferenbach DA, Artigas A, Stamme C, Chroneos ZC, Zaiss DM, Casals C, Allen JE. Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver. Science. 2017 Jun 9;356(6342):1076-1080.
Kronenberg NM, Liehm P, Steude A, Knipper JA, Borger JG, Scarcelli G, Franze K, Powis SJ, Gather MC. Long-term imaging of cellular forces with high precision by elastic resonator interference stress microscopy. Nat Cell Biol. 2017 Jun 19. doi: 10.1038/ncb3561.
Minutti CM*, Knipper JA*, Allen JE, Zaiss DM. Tissue-specific contribution of macrophages to wound healing. Semin Cell Dev Biol. 2017 Jan;61:3-11. (* Shared first author)
Knipper JA*, Willenborg S*, Brinckmann J, Bloch W, Maaß T, Wagener R, Krieg T, Sutherland T, Munitz A, Rothenberg ME, Niehoff A, Richardson R, Hammerschmidt M, Allen JE, Eming SA. Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair. Immunity. 2015 Oct 20;43(4):803-16. (* Shared first author)
Willenborg S, Lucas T, van Loo G, Knipper JA, Krieg T, Haase I, Brachvogel B, Hammerschmidt M, Nagy A, Ferrara N, Pasparakis M, Eming SA. CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair. Blood. 2012 Jul 19;120(3):613-25.