Sonja Haupt, Postdoc
Location: Office 1.08, Ashworth Laboratories
I joined Rose’s Lab in November 2015 and I am currently working on targeting intracellular signalling molecules in human T cells as a viable strategy to improve adoptive T cell therapy. I am using CRISPR/Cas9 manipulation to delete expression of PTPN22 in primary human T cells to test whether that improves their anti-tumour effector function.
Main laboratory techniques
- Flow cytometry
- In vitro culture
- Molecular biology techniques
Since February 2017
Committee member of Edinburgh Cancer Immunology
Since November 2016
Immunology 3 Tutorials (Providing tutorial for group of 8-12 students)
Haupt S, Söntgerath VS, Leipe J, Schulze-Koops H, Skapenko A. Methylation of an intragenic alternative promoter regulates transcription of GARP. Biochim Biophys Acta. 2016 Feb;1859(2):223-34.
Zhou Q*, Haupt S*, Kreuzer JT, Hammitzsch A, Proft F, Neumann C, Leipe J, Witt M, Schulze-Koops H, Skapenko A. Decreased expression of miR-146a and miR-155 contributes to an abnormal Treg phenotype in patients with rheumatoid arthritis. Ann Rheum Dis. 2015 Jun;74(6):1265-74. (*Shared first author)
Zhou Q, Haupt S, Prots I, Thümmler K, Kremmer E, Lipsky PE, Schulze-Koops H, Skapenko A. miR-142-3p is involved in CD25+ CD4 T cell proliferation by targeting the expression of glycoprotein A repetitions predominant. J Immunol. 2013 Jun 15;190(12):6579-88.
Haupt S, Tisdale M, Vincendeau M, Clements MA, Gauthier DT, Lance R, Semmes OJ, Turqueti-Neves A, Noessner E, Leib-Mösch C, Greenwood AD. Human endogenous retrovirus transcription profiles of the kidney and kidney-derived cell lines. J Gen Virol. 2011 Oct;92(Pt 10):2356-66.
Scherb J, Kreissl J, Haupt S, Schieberle P. Quantitation of S-methylmethionine in raw vegetables and green malt by a stable isotope dilution assay using LC-MS/MS: comparison with dimethyl sulfide formation after heat treatment. J Agric Food Chem. 2009 Oct 14;57(19):9091-6.
Postdoc on adoptive T cell therapy
Institute of Immunology and Infection Research, University of Edinburgh
Research group of Prof. Dr. Rose Zamoyska
05/2010 – 08/2015
PhD on regulatory T cell function in rheumatoid arthritis
Division of Rheumatology and Clinical Immunology, LMU Munich
Research group of Dr. Alla Skapenko
10/2007 – 08/2009
MSc in Biochemistry at TU Munich
10/2004 – 08/2007
BSc in Biology at University of Münster