Publications

Garth L. Burn, Georgina H. Cornish, Katarzyna Potrzebowska, Malin Samuelsson, Juliette Griffie, Sophie Minoughan, Mark Yates, George Ashdown, Nicolas Pernodet, Vicky L. Morrison, Cristina Sanchez-Blanco, Harriet Purvis, Fiona Clarke, Rebecca J. Brownlie, Timothy J. Vyse, Rose Zamoyska, Dylan M. Owen, L.M. Svensson, and A.P. Cope. 2016. Superresolution imaging of the cytoplasmic phosphatase PTPN22 links integrin-mediated T cell adhesion with autoimmunity. Sci Signal in press:

Watson, R., T. McNeilly, K. Watt, J. Pemberton, J. Pilkington, M. Waterfall, P. Hopper, D. Cooney, R. Zamoyska, and D. Nussey. 2016. Cellular and humoral immunity in a wild mammal: Variation with age & sex and association with over-winter survival. Ecology and Evolution 6:8695-8705

Vermeren, S., K. Miles, J.Y. Chu, D. Salter, R. Zamoyska, and M. Gray. 2016. PTPN22 Is a Critical Regulator of Fcgamma Receptor-Mediated Neutrophil Activation. J Immunol 197:4771-4779

Sood S, Brownlie RJ, Garcia C, Cowan G, Salmond RJ, Sakaguchi S, Zamoyska R (2016) Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice. J Immunol 197:429-440

Salmond, R.J., R.J. Brownlie, O. Meyuhas, and R. Zamoyska. 2015. Mechanistic Target of Rapamycin Complex 1/S6 Kinase 1 Signals Influence T Cell Activation Independently of Ribosomal Protein S6 Phosphorylation. J Immunol 195:4615-4622

Salmond, R.J., R.J. Brownlie, V.L. Morrison, and R. Zamoyska. 2014. The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals. Nat Immunol 15:875-883  doi:10.1038/ni.2958

Casas, J., J. Brzostek, V.I. Zarnitsyna, J.S. Hong, Q. Wei, J.A. Hoerter, G. Fu, J. Ampudia, R. Zamoyska, C. Zhu, and N.R. Gascoigne. 2014. Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor. Nat Commun 5:5624 http://www.nature.com/ncomms/2014/141127/ncomms6624/extref/

Borger, J.G., R. Zamoyska, and D.M. Gakamsky. 2014. Proximity of TCR and its CD8 coreceptor controls sensitivity of T cells. Immunol Lett 157:16-22

Borger, J.G., A. Filby, and R. Zamoyska. 2013. Differential polarisation of Csk between naïve and antigen-experienced CD8+ T cells. J. Immunol. 190:3089-99

Brownlie, R.J., and R. Zamoyska. 2013. T cell receptor signalling networks: branched, diversified and bounded. Nat Rev Immunol 13:257-269

Brownlie, R, Miosge, L, Vassilakos, D, Svensson, L., Cope, A and Zamoyska, R. 2012 Loss of PTPN22 improves murine regulatory T cell function by influencing T cell receptor and integrin signaling. Science Signaling 5:ra87

Caserta, S., J.G. Borger, and R. Zamoyska. 2012. Central and effector memory CD4 and CD8 T-cell responses to tumor-associated antigens. Crit Rev Immunol 32:97-126

Nussey, D.H., K. Watt, J.G. Pilkington, R. Zamoyska, and T.N. McNeilly. 2012. Age-related variation in immunity in a wild mammal population. Aging Cell 11:178-180

Caserta, S., N. Nausch, A. Sawtell, R. Drummond, T. Barr, A.S. Macdonald, F. Mutapi, and R. Zamoyska. 2012. Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells. PLoS One 7:e35466

Tsun, A., I. Qureshi, J.C. Stinchcombe, M.R. Jenkins, M. de la Roche, J. Kleczkowska, R. Zamoyska, and G.M. Griffiths. 2011. Centrosome docking at the immunological synapse is controlled by Lck signaling. J Cell Biol 192:663-674

Salmond, R.J., and R. Zamoyska. 2011. The influence of mTOR on T helper cell differentiation and dendritic cell function. European journal of immunology 41:2137-2141

Borger, J.G., J.M. Cardenas-Maestre, R. Zamoyska, and R.M. Sanchez-Martin. 2011. Novel strategy for microsphere-mediated DNA transfection. Bioconjugate chemistry 22:1904-1908

Salmond, R.J., and R. Zamoyska. 2010. How does the mammalian target of rapamycin (mTOR) influence CD8 T cell differentiation? Cell Cycle 9:2952-2957

Salmond, R.J., A. Filby, N. Pirinen, A.I. Magee, and R. Zamoyska. 2010. Mislocalization of Lck impairs thymocyte differentiation and can promote development of thymomas. Blood 117:108-117

Caserta, S., J. Kleczkowska, A. Mondino, and R. Zamoyska. 2010. Reduced functional avidity promotes central and effector memory CD4 T cell responses to tumor-associated antigens. J Immunol 185:6545-6554

Salmond, R.J., A. Filby, I. Qureshi, S. Caserta, and R. Zamoyska. 2009. T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance. Immunological reviews 228:9-22

Salmond, R.J., J. Emery, K. Okkenhaug, and R. Zamoyska. 2009. MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells. J Immunol 183:7388-7397