Publications

Brownlie RJ, Garcia C, Ravasz M, Zehn D, Salmond RJ, Zamoyska R. Resistance to TGFβ suppression and improved anti-tumor responses in CD8+ T cells lacking PTPN22. Nat Commun. 2017 Nov 7;8(1):1343. doi: 10.1038/s41467-017-01427-1.

Clarke F, Jordan CK, Gutiérrez-Martinez E, Bibby JA, Sanchez-Blanco C, Cornish GH, Dai X, Rawlings DJ, Zamoyska R, Guermonprez P, Cope AP, Purvis HA. Protein tyrosine phosphatase PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells. PLoS One. 2017 Oct 17;12(10):e0186625. doi: 10.1371/journal.pone.0186625. eCollection 2017.

Purvis HA, Clarke F, Jordan CK, Blanco CS, Cornish GH, Dai X, Rawlings DJ, Zamoyska R, Cope AP. Protein tyrosine phosphatase PTPN22 regulates IL-1β dependent Th17 responses by modulating dectin-1 signaling in mice. Eur J Immunol. 2017 Sep 25. doi: 10.1002/eji.201747092. [Epub ahead of print]

Tan TCJ, Knight J, Sbarrato T, Dudek K, Willis AE, Zamoyska R. Suboptimal T-cell receptor signaling compromises protein translation, ribosome biogenesis, and proliferation of mouse CD8 T cells. Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6117-E6126. doi: 10.1073/pnas.1700939114. Epub 2017 Jul 10.

Borger JG, Morrison VL, Filby A, Garcia C, Uotila LM, Simbari F, Fagerholm SC, Zamoyska R. Caveolin-1 Influences LFA-1 Redistribution upon TCR Stimulation in CD8 T Cells. J Immunol. 2017 Aug 1;199(3):874-884. doi: 10.4049/jimmunol.1700431. Epub 2017 Jun 21.

Watson RL, McNeilly TN, Watt KA, Pemberton JM, Pilkington JG, Waterfall M, Hopper PR, Cooney D, Zamoyska R, Nussey DH. Cellular and humoral immunity in a wild mammal: Variation with age & sex and association with overwinter survival. Ecol Evol. 2016 Nov 15;6(24):8695-8705. doi: 10.1002/ece3.2584. eCollection 2016 Dec.

Vermeren S, Miles K, Chu JY, Salter D, Zamoyska R, Gray M. PTPN22 Is a Critical Regulator of Fcγ Receptor-Mediated Neutrophil Activation. J Immunol. 2016 Dec 15;197(12):4771-4779. [Link] Epub 2016 Nov 2.

Burn GL, Cornish GH, Potrzebowska K, Samuelsson M, Griffié J, Minoughan S, Yates M, Ashdown G, Pernodet N, Morrison VL, Sanchez-Blanco C, Purvis H, Clarke F, Brownlie RJ, Vyse TJ, Zamoyska R, Owen DM, Svensson LM, Cope AP. Superresolution imaging of the cytoplasmic phosphatase PTPN22 links integrin-mediated T cell adhesion with autoimmunity. Sci Signal. 2016 Oct 4;9(448):ra99.

Goplen NP, Saxena V, Knudson KM, Schrum AG, Gil D, Daniels MA, Zamoyska R, Teixeiro E. IL-12 Signals through the TCR To Support CD8 Innate Immune Responses. J Immunol. 2016 Sep 15;197(6):2434-43. doi: 10.4049/jimmunol.1600037. Epub 2016 Aug 12.

Sood S, Brownlie RJ, Garcia C, Cowan G, Salmond RJ, Sakaguchi S, Zamoyska R. Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice. J Immunol. 2016 Jul 15;197(2):429-40. doi: 10.4049/jimmunol.1502656. Epub 2016 Jun 10.

Salmond, R.J., R.J. Brownlie, O. Meyuhas, and R. Zamoyska. 2015. Mechanistic Target of Rapamycin Complex 1/S6 Kinase 1 Signals Influence T Cell Activation Independently of Ribosomal Protein S6 Phosphorylation. J Immunol 195:4615-4622

Salmond, R.J., R.J. Brownlie, V.L. Morrison, and R. Zamoyska. 2014. The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals. Nat Immunol 15:875-883  doi:10.1038/ni.2958

Casas, J., J. Brzostek, V.I. Zarnitsyna, J.S. Hong, Q. Wei, J.A. Hoerter, G. Fu, J. Ampudia, R. Zamoyska, C. Zhu, and N.R. Gascoigne. 2014. Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor. Nat Commun 5:5624 http://www.nature.com/ncomms/2014/141127/ncomms6624/extref/

Borger, J.G., R. Zamoyska, and D.M. Gakamsky. 2014. Proximity of TCR and its CD8 coreceptor controls sensitivity of T cells. Immunol Lett 157:16-22

Borger, J.G., A. Filby, and R. Zamoyska. 2013. Differential polarisation of Csk between naïve and antigen-experienced CD8+ T cells. J. Immunol. 190:3089-99

Brownlie, R.J., and R. Zamoyska. 2013. T cell receptor signalling networks: branched, diversified and bounded. Nat Rev Immunol 13:257-269

Brownlie, R, Miosge, L, Vassilakos, D, Svensson, L., Cope, A and Zamoyska, R. 2012 Loss of PTPN22 improves murine regulatory T cell function by influencing T cell receptor and integrin signaling. Science Signaling 5:ra87

Caserta, S., J.G. Borger, and R. Zamoyska. 2012. Central and effector memory CD4 and CD8 T-cell responses to tumor-associated antigens. Crit Rev Immunol 32:97-126

Nussey, D.H., K. Watt, J.G. Pilkington, R. Zamoyska, and T.N. McNeilly. 2012. Age-related variation in immunity in a wild mammal population. Aging Cell 11:178-180

Caserta, S., N. Nausch, A. Sawtell, R. Drummond, T. Barr, A.S. Macdonald, F. Mutapi, and R. Zamoyska. 2012. Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells. PLoS One 7:e35466

Tsun, A., I. Qureshi, J.C. Stinchcombe, M.R. Jenkins, M. de la Roche, J. Kleczkowska, R. Zamoyska, and G.M. Griffiths. 2011. Centrosome docking at the immunological synapse is controlled by Lck signaling. J Cell Biol 192:663-674

Salmond, R.J., and R. Zamoyska. 2011. The influence of mTOR on T helper cell differentiation and dendritic cell function. European journal of immunology 41:2137-2141

Borger, J.G., J.M. Cardenas-Maestre, R. Zamoyska, and R.M. Sanchez-Martin. 2011. Novel strategy for microsphere-mediated DNA transfection. Bioconjugate chemistry 22:1904-1908

Salmond, R.J., and R. Zamoyska. 2010. How does the mammalian target of rapamycin (mTOR) influence CD8 T cell differentiation? Cell Cycle 9:2952-2957

Salmond, R.J., A. Filby, N. Pirinen, A.I. Magee, and R. Zamoyska. 2010. Mislocalization of Lck impairs thymocyte differentiation and can promote development of thymomas. Blood 117:108-117

Caserta, S., J. Kleczkowska, A. Mondino, and R. Zamoyska. 2010. Reduced functional avidity promotes central and effector memory CD4 T cell responses to tumor-associated antigens. J Immunol 185:6545-6554

Salmond, R.J., A. Filby, I. Qureshi, S. Caserta, and R. Zamoyska. 2009. T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance. Immunological reviews 228:9-22

Salmond, R.J., J. Emery, K. Okkenhaug, and R. Zamoyska. 2009. MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells. J Immunol 183:7388-7397